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Umesh R. Desai, Ph.D.


Professor
Department of Medicinal Chemistry

Location:  Virginia Biotechnology Research Park, Suite 212
Phone: (804) 828-7328
Email: urdesai@vcu.edu

Mailing Address

School of Pharmacy - Dept of Medicinal Chemistry
BioTech One, Suite 205
800 E. Leigh St.
P.O. Box 980540
Richmond, VA 23298-0540
Fax: (804) 827-3664


Area of Focus

  • Rational Design of Cardiovascular Drugs
  • Allosteric Activators of Antithrombin
  • Computational Studies on Heparin - Protein Interaction
  • Rational Design of Macromolecular Scaffolds as Inhibitors of Viral Infection
  • Allosteric Inhibitors of Coagulation Factors (IIa, Xa, IXa, XIa, VIIa)
  • Structure of Low Molecular Weight Heparins

Education

  • B.S., Chemistry (M. S. University of Baroda, India, 1983)
  • M.S., Organic Chemistry (Indian Institute of Technology - Bombay, 1985)
  • Ph.D., Organic Chemistry (Indian Institute of Technology - Bombay, 1991)

Post-Graduate Training

  • Fellowship - Postdoctoral Training (University of Iowa – Iowa City, 1993)
  • Fellowship - Postdoctoral Trainint (Massachusetts Institute of Technology, Cambridge, 1994)

Academic Appointments/Professional Experience

  • (1998 - 2004) Assistant Profesor of Medicinal Chemsitry, Virginia Commonwealth University
  • (2004 - 2007) Associate Professor of Medicinal Chemistry, Virginia Commonwealth University
  • (2007 - Present) Professor of Medicinal Chemistry, Virginia Commonwealth University
  • (2009 - 2014) Interim Director of Institute for Structural Biology and Drug Discovery,
  • (2014 - Present) Director of Institute for Structural Biology, Drug Discovery and Development,

Publications

PubMed Search
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  • Books/Book Chapters
    • ‘Glycosaminoglycans – Chemistry and Biology’, a volume of Methods in Molecular Biology, Springer, NY (2014). Editor: Kuberan Balagurunathan, Hiroshi Nakato and Umesh R. Desai
    • Sankaranarayanan, N. V.; Sarkar, A.; Desai, U. R.; Mosier, P. D.* Designing ‘high-affinity, high-specificity’ glycosaminoglycan sequences through computerized modeling. Methods in Molecular Biology 2015, 1229, 289-314. (PMID: 25325961)
    • Al-Horani, R. A.; Karuturi, R.; Verespy, S. III; Desai, U. R.* Synthesis of glycosaminoglycan mimetics through sulfation of polyphenols. Methods in Molecular Biology 2015, 1229, 49-67. (PMID: 25325944)
    • Boothello, R. S.; Al-Horani, R. A.; Desai, U. R.* Glycosaminoglycan–protein interaction studies using fluorescence spectroscopy. Methods in Molecular Biology 2015, 1229, 335-353. (PMID: 25325964)
    • Liang, A.;* Desai, U. R. Studying glycosaminoglycan–protein interactions using capillary electrophoresis. Methods in Molecular Biology 2015, 1229, 355-375. (PMID: 25325965)
  • Patents
    • Desai, U. R.; Gunnarsson, G. T. Sulfated bis-cyclic agents. United States Patent, US 7,402,594 issued July 22, 2008.
    • Desai, U. R.; King, J. T. Method for finger-printing heparins. United States Patent, US 8,262,881 issued September 11, 2012.
    • Desai, U. R.; Henry, B. L.; Liang, A.; Thakkar, J. N.; Mangrum, J. B.; Torres Filho, I.; Spiess, B. D.; Saluja, B.; Sakagami, M. Cinnamic acid-based oligomers and uses thereof. United States Patent Application Publication, # US 8,491,872 issued July 23, 2013.
    • Desai, U. R.; Henry, B. L.; Liang, A.; Thakkar, J. N.; Mangrum, J. B.; Torres Filho, I.; Spiess, B. D.; Saluja, B.; Sakagami, M. Cinnamic acid-based oligomers and uses thereof – Divisional 1. United States Patent, US 8,613,909 issued December 24, 2013.
    • Desai, U. R.; Henry, B. L.; Liang, A.; Thakkar, J. N.; Mangrum, J. B.; Torres Filho, I.; Spiess, B. D.; Saluja, B.; Sakagami, M. Cinnamic acid-based oligomers and uses thereof – Divisional II Application. United States Patent Application Publication, US 8,993,620 issued March 31, 2015.
  • Recent Publications
    • Mehta, A. Y.; Mohammed, B. M.; Thakkar, J. N.; Martin, E. J.; Brophy, D. F.; Gailani, D.; Desai, U. R.* Allosterism-based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Iba-binding and heparin-binding site of thrombin. Journal of Thrombosis and Hemostasis 2016, 14, 828–838. (PMID: 26748875)
    • Verespy, S. III; Mehta, A. Y.; Afosah, D.; Al-Horani, R. A.; Desai, U. R.* Allosteric partial inhibition of monomeric proteases. Sulfated coumarins induce regulation, not just inhibition, of thrombin. Scientific Reports 2016, 6, 24043. (PMID: 27053426)
    • Mosier, P. D.; Chiang, M.-J.; Lin, Z.; Jin, Y.; Althufiari, B.; Musayev, F.; Safo, M.; Zhou, Q.; Xie, H.*; Desai, U. R.* Broad spectrum anti-influenza agents by inhibiting self-association of matrix protein 1. Scientific Reports 2016, 6, 32340. (PMID: 27573445)
    • Sepuru, K. M.; Nagarajan, B.; Desai, U. R.; Rajarathnam, K.* Molecular basis of chemokine CXCL5-glycosaminoglycan interactions. Journal of Biological Chemistry 2016, 291, 20539–20550. (PMID: 27471273)
    • Patel, N. J.; Sharon, C.; Baranwal, C.; Boothello, R. S.; Desai, U. R.; Patel, B. B.* Heparan sulfate hexasaccharide selectively inhibits cancer stem cells by activating p38 MAP kinase. Oncotarget 2016, 7, 84608–84622. (PMID: 27705927)
    • Afosah, D.; Al-Horani, R. A.; Sankaranarayanan, NV.; Desai, U. R.* Potent, selective, allosteric inhibition of human plasmin by sulfated non-saccharide glycosaminoglycan mimetics. Journal of Medicinal Chemistry 2017, 60, 641–657. (PMID: 27976897)
    • Sankaranarayanan, NV.; Strebel, T. R.; Boothello, R. S.; Sheerin, K. J.; Raghuraman, A.; Salas, F.; Mosier, P. D.; Watermeyer, N.; Oscarson, S.;* Desai, U. R.* A hexasaccharide containing rare 2-O-sulfated glucuronic acid residues selectively activates heparin cofactor II. Angewandte Chemie International Edition English 2017, 56, 2312–2317. (PMID: 28124818)
    • Nagarajan, B.; Sankaranarayanan, NV.; Patel, B. B.; Desai, U. R.* A molecular dynamics-based algorithm for evaluating the glycosaminoglycan mimicking potential of synthetic, homogenous, sulfated small molecules. PLoS One 2017, 12, e0171619. (PMID: 28182755)