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Brad E. Windle, Ph.D.


Affiliate Associate Professor
Department of Medicinal Chemistry

Location:  Massey Cancer Center, Room 319
Phone: (804) 628-1956
Email: bwindle@vcu.edu
Web: Research Website

Mailing Address

School of Pharmacy - Dept of Medicinal Chemistry
BioTech One, Suite 205
800 E. Leigh St.
P.O. Box 980540
Richmond, VA 23298-0540


Area of Focus

  • Computational chemistry and biology in drug research

Education

  • Ph.D., Medicinal Chemistry (University of Maryland, Baltimore County, 1986)

Post-Graduate Training

  • Fellowship - Post-doctoral fellow (The Salk Institute, 1990)

Academic Appointments/Professional Experience

  • 3/1/2000 - Present. Associate Professor, Virginia Commonwealth University
  • 1990-2000. Assistant professor and member, The Cancer Therapy and Research Center and the University of Texas Health Science Center at San Antonio

Research Interests

  • My laboratory is focused on developing new technologies for drug development using bioinformatics. Cells are defined by their genomics and proteomics, which govern their growth and response to the environment. Drugs are defined by their structure, interaction with cellular targets and cellular processes. Cells are remarkable sensors of both specific and non-specific perturbations caused by drugs. The advent of microarrays has made possible the global analysis of gene expression. We are using gene expression profile patterns to define how cells respond to drugs and the pathways involved. The patterns we identify represent fingerprints for each drug, which we use for functional categorization of drugs and the pathways with which the drugs interact. Our goal is to define how structure relates to pathway interactions.

Publications

PubMed Search
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  • Patents
    • Windle, BE, (1998) "Color imaging method for mapping stretched DNA hybridized with fluorescently labeled oligonucleotide probes" U.S. Patent no. 5,707,797.
    • Chen, SF, Maine, I , Kerwin, SM, Fletcher, TM, Salazar, M, Mamiya, B, Wajima, M, Windle, BE, (1999) "Methods for modulation and inhibition of telomerase" U.S. Patent no. 6,004,939.
    • Chen, SF, Maine, I , Kerwin, SM, Fletcher, TM, Salazar, M, Mamiya, B, Wajima, M, Windle, BE, (2000) "Methods and compositions for modulation and inhibition of telomerase in vitro" U.S. Patent no 6,054,442.
    • Windle, BE, Qiu, M, Chen, SF, Fletcher, TM, Maine, I, (1999) “Rapid and sensitive assays for detecting and distinguishing between processive and non-processive telomerase activities” U.S. Patent no 5,856,096
    • Windle, BE, (2003) “Methods and compositions for extended and super-extended DNA and hybridization mapping” U.S. Patent no 6,638,715
    • Chen, SF, Maine, I, Kerwin, SM, Fletcher, TM, Salazar, M, Mamiya, B, Wajima, M, Windle, BE, (2003) “Methods for modulation and inhibition of telomerase” U.S. Patent no 6,593,306
  • Recent Publications
    • Scian, M.J., Carchman, E.H., Mohanraj, L., Stagliano, K.E.R., Anderson, M.A.E., Deb, D., Crane, B.M., Kiyono, T., Windle, B., Deb, S.P. and Deb, S. Wild-type p53 and p73 negatively regulate expression of proliferation related genes. Oncogene, advance publication, 2007.
    • Ko, D., Xu, W., and Windle, B. Gene Function Classification Using NCI-60 Cell Line Gene Expression Profiles. Computational Biology and Chemistry 29:412-419, 2005.
    • Taylor, S., Smith, S., Windle, B., Guiseppi-Elie, A. Impact of Surface Chemistry and Blocking Strategies in DNA Microarrays. Nucleic Acids Research 31:1-19, 2003.
    • Windle, B and Guiseppi-Elie, A. Microarrays and Gene Expression Profiling Applied to Drug Research. (2003) In: Burger's Medicinal Chemistry and Drug Discovery, 6th edition (D. Abraham, ed.).
    • Ko D and Windle B. Enriching for correct prediction of biological processes using a combination of diverse classifiers. BMC Bioinformatics 12:189-201, 2011.