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Department of Medicinal Chemistry
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Department of Medicinal Chemistry
Virginia Biotechnology Research Park, Suite 205
School of Pharmacy - Dept of Medicinal Chemistry
BioTech One, Suite 205
800 E. Leigh St.
P.O. Box 980540
Richmond, VA 23298-0540
Area of Focus
Drug design and development
Ph.D., Medicinal Chemistry (Peking Union Medical College, Beijing, China, 1997)
B.S., Chemistry (Nankai University, Tianjin, China, 1992)
Post-Doc - Postdoctoral Research Scholar (College of Pharmacy, Univesity of Iowa, 2000)
Fellowship - Alexander von Humboldt Fellow (University of Ulm, Germany, 1999)
Post-Doc - Postdoctoral Researcher, Institute of Chemistry (Chinese Academy of Sciences, Beijing, China, 1997-1999)
3/2001 - 7/2004. Research Associate, Dept of Medicinal Chemistry, University of Minnesota
(2004 - 2010) Assistant Professor, Department of Medicinal Chemistry
(2010 - 2016) Associate Professor, Department of Medicinal Chemistry
(2016 - Present) Professor, Department of Medicinal Chemistry
My laboratory has a longstanding interests in design and development of novel ligands targeting G-protein coupled receptors (GPCRs) and their potential application in pharmacology, biochemistry, biology, and therapy. Two families of GPCRs, opioid receptors and chemokine receptors, have been studied vigorously in our lab.
Position available: Postdoctoral Research Fellow in Medicinal Chemistry and Drug Discovery Job Description: A postdoctoral fellow position is available in the laboratory of Prof. Yan Zhang, Virginia Commonwealth University. We are seeking highly motivated synthetic organic chemists and medicinal chemists to join a comprehensive drug discovery program. Dr. Zhang’s lab is conducting highly interdisciplinary research focused on pre-clinical development of novel drug candidates, which covers chemical synthesis, medicinal chemistry, biochemical and biophysical assays, and molecular modeling. The successful candidate will be involved in design and synthesis of small molecule targeting G-protein coupled receptors. The duties will include design, synthesis, and biological characterization of novel lead compounds to develop drug candidates in treating varies types of diseases, including substance abuse and addiction, cancer, AIDS, and neurological disorders. Applicants should have a PhD degree in synthetic organic chemistry or medicinal chemistry. This position requires extensive experience in designing synthetic routes for novel compounds, solving challenging synthetic problems, and SAR analysis. Applicants also need to be able to apply NMR, HPLC, and MS methods to solve organic chemistry inquiries. Excellent oral and written communication skills in English are also required. To apply, please submit cover letter, CV, and contact information for three references combined into one PDF file by e-mail to: email@example.com. Contact: Yan Zhang, Associate Professor, Department of Medicinal Chemistry, Virginia Commonwealth University, Biotech I, 800 E Leigh Street, Richmond, VA 23298.
Guo Li, Karen Watson, Robert W. Buckheit and Yan Zhang. Total Synthesis of Anibamine, a Novel Natural Product as Chemokine Receptor CCR5 Antagonist. Organic Letters, 2007, 9, 2043-2046.
Yunyun Yuan, Guo Li, Hengjun He, David L. Stevens, Patrick Kozak, Krista L. Scoggins, Pallabi Mitra, Phillip M. Gerk, Dana E. Selley, William L. Dewey, Yan Zhang. Identification of 6?- and 6?-N-Heterocyclic Substituted Naltrexamine Derivatives as Novel Leads to Development of Mu Opioid Receptor Selective Antagonists. ACS Chem. Neurosci. 2011, 2 (7), 346–351. PMCID: PMC3369747.
Feng Zhang, Saheem Zaidi, Kendra M. Haney, Glen E. Kellogg, Yan Zhang. Regio- and Stereo-selective Syntheses of the Natural Product CCR5 Antagonist Anibamine and its Three Olefin Isomers. J. Org. Chem. 2011, 76 (19), 7945–7952. PMID: 21875065. PMCID: PMC3197777.
Yunyun Yuan, Orgil Elbegdorj, Jianyang Chen, Shashidhar K. Akubathini, Feng Zhang, David L. Stevens, Irina O. Beletskaya, Krista L. Scoggins, Dana E. Selley, Hamid I. Akbarali, William L. Dewey, Yan Zhang. Design, Synthesis, and Biological Evaluation of 17-Cyclopropylmethyl-3,14ß-dihydroxy-4,5a-epoxy-6ß-[(4’-pyridyl)carboxamido]morphinan Derivatives as Peripheral Selective Mu Opioid Receptor Antagonists. J. Med. Chem. 2012, 55(22), 10118-29. PMID: 23116124. PMCID: PMC3527108.
Yunyun Yuan, Christopher K. Arnatt, Nazira El-Hage, Seth M. Dever, Joanna C. Jacob, Dana E. Selley, Kurt F. Hauser, Yan Zhang. A Bivalent Ligand Targeting the Putative Mu Opioid Receptor and Chemokine Receptor CCR5 Heterodimers: Binding Affinity versus Functional Activities. MedChemComm. 2013, 4, 847-851. PMID: 23682308. PMCID: PMC3652433.
Nazira El-Hage, Elizabeth M. Podhaizer, Seth M. Dever, Christopher K. Arnett, Yan Zhang, Kurt F. Hauser. Maraviroc fails to inhibit HIV-1 entry in astroglial exposed to morphine: Implication for new therapeutic against NeuroAIDS in drug abuse population. AIDS, 2013, 27, 2181-2190. PMID: 23751259. PMCID: PMC3918492.
Saheem Zaidi, Christopher K. Arnatt, Hengjun He, Dana Selley, Philip Mosier, Glen Kellogg, Yan Zhang. Binding Mode Characterization of 6?- and 6?-N-Heterocyclic Substituted Naltrexamine Derivatives in Opioid Receptor Crystal Structures: Application of the “Message–Address” Concept in Development of Mu Opioid Receptor Selective Antagonists. Bioorg. Med. Chem. 2013, 21, 6405-6413. PMID: 24055076. PMCID: PMC3831368.
Yunyun Yuan, Saheem A. Zaidi, Orgil Elbegdorj, Lindsey C. K. Aschenbach, Guo Li, David L. Stevens, Krista L. Scoggins, William L. Dewey, Dana E. Selley, Yan Zhang. Design, Syntheses, and Biological Evaluation of 14-Heteroaromatic Substituted Naltrexone Derivatives: Pharmacological Profile Switch from Mu Opioid Receptor Selectivity to Mu/Kappa Opioid Receptor Dual Selectivity. J. Med. Chem. 2013, 56, 9156-69. PMID: 24144240. PMCID: PMC4373589.
Christopher K. Arnatt, Saheem A. Zaidi, Zhu Zhang, Guo Li, Amanda C. Richardson, Joy L. Ware, Yan Zhang. Design, syntheses, and characterization of pharmacophore based chemokine receptor CCR5 antagonists as anti prostate cancer agents. Euro. J. Med. Chem. 2013, 69, 647-658. PMID: 24095757.
Yunyun Yuan, Saheem A. Zaidi, David L. Stevens, Krista L. Scoggins, Philip D. Mosier, Glen E. Kellogg, William L. Dewey, Dana E. Selley, Yan Zhang. Design, Synthesis, and Pharmacological Characterization of 17-Cyclopropylmethyl-3,14ß-dihydroxy-4,5a-epoxy-6a-(isoquinoline-3'-carboxamido)morphinan (NAQ) Analogues as Potent Opioid Receptor Ligands. Bioorg. Med. Chem. 2015, 23, 1701-1715.