Qingguo Xu, PhD
Assistant Professor
Department of Pharmaceutics
Faculty/Staff picture
  •   Smith Building, Room 454C
  • School of Pharmacy - Dept of Pharmaceutics
    410 N 12th Street
    P.O. Box 980533
    Richmond, VA 23298-0533
  •  (804) 828-6431
    (804) 828-8359

Area of Focus

  • OPEN POSITIONS: Postdoc fellowship positions are available in Prof. Qingguo Xu's lab. Passionate and driven researchers with a strong background in polymers, biomaterials, nanomedicine, drug delivery or other biomedical research are welcome to apply. Qualified applicants are asked to submit a cover letter with a brief description of research experience, interests and career goals (2 pages), a CV, and contact information for three references to qxu@vcu.edu. The positions will remain open until filled.
  • PhD candidates: We are welcoming self-motivated, talented PhD student candidate for our Pharmaceutical Sciences (PhD) program. VCU pharmacy ranks #17 by US News, and the PI has active NIH (R01) and FDA-funded nanomedicine / drug delivery research program. PhD students will get comprehensive training in translational nanomedicine.

Education

  • Ph.D., Materials Science (University of Oxford, 2009)
  • M.A., Materials Science (Tianjin University, China, 2004)
  • B.A., Polymer Materials and Engineering (Tianjin University, China, 2002)

Post-Graduate Training

  • Postdoctoral fellow - Ophthalmology (Wilmer Eye Institute, Johns Hopkins University School of Medicine, 2013)

Professional Experience

  • (2017 - Present) Assistant Professor, Department of Pharmaceutics, Virginia Commonwealth University School of Pharmacy
  • (2017 - Present) Assistant Professor (affiliate), Department of Ophthalmology, Virginia Commonwealth University School of Medicine
  • (2017 - Present) Assistant Professor (associate member), Massey Cancer Center, Virginia Commonwealth University School of Medicine
  • (2017 - Present) Assistant Professor (adjunct), Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • (2013 - 2017) Research Associate, Wilmer Eye Institute, Johns Hopkins University School of Medicine
  • (2008 - 2010) Process Scientist, Unilever R&D at Colworth, Bedford, United Kingdom

Professional and Scholarly Interests

  • Nanomedicine; Drug Delivery; Biomaterials; Ocular Diseases; Cancer

Research Interests

  • My research program focuses on applying engineering principles to advance our understanding of biological barriers to drugs and foreign body immune responses to biomaterials within the context of disease physiology, while developing cutting-edge nanotherapeutic-based treatments for ocular (eye) disorders, cancer and other diseases.

Publications

Patents

  • Q. Xu, Q. Pan, NJ Boylan, B. Wang, L. Luo, WJ Stark, J. Hanes. Glucocorticosteroid-loaded nanoparticles for prevention of corneal allograft rejection and neovascularization, Patent pending, WO2016025215A1, Aug 4, 2015
  • J. Fu, J. Hanes, J. Kays, Y. Yu, M. Yang, J. Cleland, W. Stark, Q. Xu, J. Yang, Sunitinib formulations and methods for use thereof in treatment of ocular disorders, Patent pending, PCT/US2015/065894, Dec 15, 2015
  • B. Slusher, J. Hanes, A. Lee, Q. Xu, J. Fu, Glutaminase inhibitor discovery and nanoparticle-enhanced delivery to pancreatic tumors, Patent pending, PCT/US2015/039579, Jul 8, 2015
  • J. Hanes, Q. Xu, N. Boylan, Nanoparticles with enhanced mucosal penetration or decreased inflammation, Patent pending, WO2013090804A2, Jun 20, 2013
  • F. Kashiwabuchi, J. Hanes, H. Mao, P. McDonnell, H. Patel, Q. Xu, S. Zhang, Drug loaded microfiber sutures for ophthalmic application, Granted Patent number, US9,533,068, Jan 3, 2017
  • A. Bot, J. Peng, Q. Xu, S. Zhu, Aerated oil containing sucrose fatty acid ester and hydrophobin, Patent pending, WO 2013174585 A1, Nov 28, 2013
  • D. Aldred, A. Bot, P. Knight, J. Peng, J. Wieringa, Q. Xu, S. Zhu, Method for production of aerated water-in-oil emulsions and aerated emulsions, Granted Patent number, EP2833729 B1, Dec 9, 2015
  • A. Williams, Q. Xu, S. Zhu, Aerated chocolate composition and preparation thereof. Granted Patent number, EP2621287 B1, Apr 8, 2015
  • A. Bot, M. Hemelaar, Q. Xu, S. Zhu, Edible fat continuous product comprising sucrose fatty acid ester and particulate anti-spattering agent, Patent pending, WO2015036164 (PCT/EP2014066412), Mar 19, 2015

Recent Publications

  • C. Schneider*, Q. Xu*, N. Boylan*, J. Chisholm, B. Tang, B. Schuster, A. Henning, L. Ensign, E. Lee, P. Adstamonghonhul, B. Simons, X. Gong, S. Wang, T. Yu, M. Boyle, J. Suk, J. Hanes, Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation, Science Advances, 2017, 3(4): e1601556.
  • A. Elgogary*, Q. Xu*, B. Poore, J. Alt, S. Zimmermann, L. Zhao, J. Fu, B. Chen, S. Xia, Y. Liu, M. Neisser, C. Nguyen, R. Lee, J. Park, J. Reyes, T. Hartung, C. Rojas, R. Rais, T. Tsukamoto, G. Semenza, J. Hanes, B. Slusher, A. Le, Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer, Proc Natl Acad Sci USA, 2016, 113(36):E5328-5336.
  • Q. Xu, L. Ensign, N. L. Boylan, A. Schon, X. Gong, J. Yang, N. Lamb, S. Cai, T. Yu, E. Freire, J. Hanes, Impact of surface polyethylene glycol (PEG) density on biodegradable nanoparticle transport in mucus ex vivo and distribution in vivo. ACS Nano, 2015, 9(9), 9217-9227.
  • Q. Pan*, Q. Xu*, N.J. Boylan, N.W. Lamb, D. Emmert, J. Yang, L. Tang, C.G. Eberhart, J. Hanes, W.J. Stark, Corticosteroid-loaded biodegradable nanoparticles for pretention of corneal allograft rejection in rats, J Control Release, 2015, 201, 32-40.
  • E. Nance, C. Zhang, T. Shih, Q. Xu, B. Schuster, J. Hanes, Brain-penetrating nanoparticles improve paclitaxel efficacy in malignant gliomas, ACS Nano, 2014, 8(10):10655-64.
  • Q. Xu, N. Boylan, B. Miao, S. Cai, H. Patel, J. Hanes, Scalable method to produce biodegradable nanoparticles that rapidly penetrate human mucus, J Control Release, 2013, 170, 279-286.
  • Q. Xu, N. Boylan, J. Suk, Y. Wang, E. Nance, J. Yang, P. McDonnell, R. Cone, E. Duh, J. Hanes, Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo, J Control Release, 2013,167, 76-84.
  • E. Nance, G. Woodworth, K. Sailor, T. Shih, Q. Xu, G. Swaminathan, D. Xiang, C. Eberhart, J. Hanes, A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue, Sci Transl Med, 4 (2012) 149ra119
  • D. White, S. Sengupta, M. Saxena, Q. Xu, J. Hanes, D Ding, H. Ji, and J. Mumm. Innate immune system regulation of retinal regeneration – immunomodulatory enhancement of photoreceptor replacement kinetics in zebrafish, Proc Natl Acad Sci USA, 2017, doi/10.1073/pnas.1617721114
  • F. Kashiwabuchi, K. Parikh, R. Omiadze, S. Zhang, L. Luo, H. Patel, Q. Xu, L. Ensign, H. Mao, J. Hanes, P. McDonnell, Development of absorbable, antibiotic-eluting sutures for ophthalmic surgery, Transl Vis Sci Tech. 2017, 6(1): 1.