Publications
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Books/Book Chapters
- PM Gerk and M Vore. Multidrug resistance proteins and hepatic transport of endo-and xenobiotics. Drug Metabolism and Transport: Molecular Methods and Mechanisms. Larry H. Lash, Editor. Humana Press, Inc. (2004).
Patents
- Gerk PM, Walsh SW, Landsberg AK: "Prodrugs Utilizing A Transporter Directed Uptake Mechanism", US Patent Application PCT/US2011/055231.
Recent Publications
- Gulati A, Gerk PM. Role of ATP-binding cassette (ABC) transporters in antiretroviral therapy in pregnancy. J Pharm Sci 2009; 98:2317-35. PMID: 19067393
- Gulati A, Boudinot FD, Gerk PM.Binding of lopinavir to human a1-acid glycoprotein and serum albumin. Drug Metab Disp 2009; 37:1572-5. PMID: 19439488
- Vaidya SS, Walsh SW, Gerk PM.Formation and efflux of ATP-binding cassette transporter substrate 2,4 dinitrophenyl S-glutathione from cultured human term placental villous tissue fragments. Mol Pharmaceutics 2009; 6:1689-1702. PMID: 19397308
- Lenhart J, Ling X, Gandhi R, Gerk PM, Brunzell D, Zhang S. “Clicked” bivalent ligands containing curcumin and cholesterol as multifunctional Aß oligomerization inhibitors: Design, synthesis and biological characterization. J Med Chem 2010; 53(16):6198-209. PMID:20666513
- Verenich S, Gerk PM. Therapeutic promises of 2-methoxyestradiol and its drug disposition challenges. Mol Pharmaceutics 2010: 7(6)2030-9. PMID:20831190
- Vaidya SS, Walsh SW, Gerk PM. Application of Human Placental Villous Tissue Explants to Study ABC Transporter Mediated Efflux of 2,4-Dinitrophenyl-S-Glutathione. Curr Pharm Biotechnol 2011; 12:814-23. PMID:21342117
- Gerk PM. Quantitative immunofluorescent blotting of the Multidrug Resistance-associated Protein 2 (MRP2). J Pharmacol Toxicol Methods 2011; 63:279-82. PMID:21277982
- Brophy D, Martin E, Barrett J, Nolte M, Kuhn J, Gerk P, Carr M, Pelzer H, Ezban M, Hedner U.
Monitoring rFVIIa 90 mcg kg-1 dosing in hemophiliacs: comparing laboratory response using various whole blood assays over six hours. Haemophilia 2011; 17:e949-57. PMID:21362113
- Megaraj V, Zhao T, Paumi CM, Gerk PM, Kim R, Vore M. Functional Analysis of Non-synonymous Single Nucleotide Polymorphisms of Multidrug Resistance Protein 2 (MRP2; ABCC2). Pharmacogenetics and Genomics 2011; 21:506-15. PMID: 21691255
- Mitra P, Venitz J, Yuan Y, Zhang Y, Gerk PM. Preclinical Disposition (in vitro) of Novel µ-Opioid Receptor Antagonists. Drug Metab Disp 2011; 39:1589-96. PMID:21685245
- Clay PG, Adiga R, Taylor TAH, Alsup R, Gerk PM and McRae MP. Postpartum Pharmacokinetics of Peramivir in the Treatment of 2009 H1N1 Influenza. Obstet Gynecol 2011; 118:463-7. PMID: 21768855
- Li W, Araya M, Elliott M, Kang X, Gerk PM, Halquist MS, Karnes HT, Zhang C, O'Brien PJ. Monitoring cellular accumulation of 3'-deoxy-3'-fluorothymidine (FLT) and its monophosphate metabolite (FLT-MP) by LC-MS/MS as a measure of cell proliferation in vitro." J Chromatogr B Analyt Technol Biomed Life Sci 2011; 879: 2963-70. PMID: 21925976
- Yuan Y, Li G, He H, Stevens DL, Kozak P, Scoggins KL, Mitra P, Gerk PM, Selley DE, Dewey WL and Zhang Y. Characterization of 6a- and 6ß-N-Heterocyclic Substituted Naltrexamine Derivatives as Novel Leads to Development of Mu Opioid Receptor Selective Antagonists. ACS Chemical Neuroscience 2011; 2:346-51. PMID: 22816021