School of Pharmacy

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Malgorzata Dukat, Ph.D.
Professor
Department of Medicinal Chemistry
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  •   Virginia Biotechnology Research Park, Suite 208
  • School of Pharmacy - Dept of Medicinal Chemistry
    BioTech One, Suite 205
    800 E. Leigh St.
    Box 980540
     Richmond, VA 23298-0540
  •  (804) 828-5256
    (804) 828-7404
  •  mdukat@vcu.edu

Education

  • M.S., Organic Chemistry (T. Kosciuszko Technical University Krakow,, 1983)
  • Ph.D., Medicinal Chemistry (Nicolaus Copernicus Academy of Medicine, , 1989)

Research Interests

  • Pain; Depression; Drugs of Abuse.
  • Development and elucidation of SAR (Structure-Activity Relationships) and SAFiR (Structure-Affinity Relationships) of structurally and mechanistically novel analgesics/analgesic adjuvants and antidepressants employing classical and contemporary medicinal chemistry.
  • Synthesis, molecular modeling, binding affinity, functional activity (i.e., agonist, partial agonist, allosteric modulator, inverse agonist, antagonist) at the sub-molecular (e.g. biochemical assays) and molecular (e.g. behavioral assays) levels are utilized as tools.
  • QSAR (Quantitative Structure-Activity/Affinity Relationships) of ligands that interact with LGICRs (Ligand-Gated Ion Channel Receptors), in particular 5-HT3 receptors, and GPCRs (G-Protein Coupled Receptors), particularly alpha2-adrenoceptors, using 3-D receptor models are of special interest.

Publications

Books/Book Chapters

  • Book chapters from the past five years:
  • 13. Glennon, R. A.; Dukat, M. Serotonin receptors and drugs affecting serotonergic neurotransmission. In: Foye’s Textbook of Medicinal Chemistry. D. A. 6th ed, Williams and T. Lemke, eds., Williams and Wilkins, Baltimore, 2008, pp 417-443.

Recent Publications

  • Representative publications from the past five years:
  • 74. Dogruer, D.; Lee, M.; Dukat, M.; Damaj, I.; Martin, B. R.; Glennon, R. 3-(4-Aminobutyn-1-yl)pyridines: binding at alpha4beta2 nicotinic cholinergic receptors. Bioorg. Med. Chem. Lett. 2004, 14, 523-526.
  • 75. Glennon, R.A.; Dukat, M.; Liao, L. Musings on alpha2beta4 nicotinic acetylcholine (nACh) receptor pharmacophore models. Curr. Top. Med. Chem., 2004, 4, 631-644.
  • 76. Dukat, M. 5-HT3 Serotonin receptor agonists: a pharmacophoric journey. Curr. Med. Chem. – CNS Agents, 2004, 4, 77-94.
  • 77. Glennon, R. A.; Dukat, M. alpha4beta2 nACh Receptor Pharmacophore Models. Bioorg. Med. Chem. 2004, 14, 1841-1844.
  • 78. Chang-Fong, J.; Rangisetty, J. B.; Dukat, M.; Setola, V.; Raffay, T.; Roth, B.; Glennon, R. A. 1,2,3,4-Terahydrocarbazoles as 5-HT6 serotonin receptor ligands. Bioorg. Med. Chem. Lett. 2004, 14, 1961-1964.
  • 79. Dukat, M.; Smith, C.; Herrick-Davis, K.; Teitler, M.; Glennon, R. A. Binding of tryptamine analogs at h5-HT1E receptors: a structure-affinity investigation. Bioorg. Med. Chem. 2004, 12, 2545-2552.
  • 80. Khorana, N; Pullagurla, M. R.; Dukat, M.; Young, R.; Glennon, R. A. Stimulus effects of three sulfur-containing psychoactive agents. Pharmacol. Biochem. Behav. 2004, 78, 821-826.
  • 81. Prisinzano, T.; Dukat, M.; Law, H.; Slassi, A.; MacLean, N. A.; DeLannoy, I.; Glennon, R. A. 2-(Anilino)imidazolines and 2-(benzyl)imidazolines derivatives as h5-HT1D serotonin receptor ligands. Bioorg. Med. Chem. Lett. 2004, 14, 4697-4699.
  • 82. Shelton, K. L.; Dukat, M.; Allan, A. M. Consequences of 5-HT3 receptor over-expression to the discriminative stimulus effects of ethanol. Alcohol. Clin. Exp. Res., 2004, 8, 1161-1171.
  • 83. Wesolowska, A.; Young, S.; Dukat, M.; MD-354 potentiates the antinociceptive effect of clonidine in the mouse tail-flick but not hot-plate assay. Eur. J. Pharmacol. 2004, 495, 129-136.
  • 84. Dukat, M.; Taroua, M.; Dahdouh, A.; Siripurapu, U.; Damaj, I. M.; Martin, B. R.; Glennon, R. A. (±)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents. Bioorg. Med. Chem. Lett. 2004, 14, 3651-3654.
  • 85. Lee, M.; Rangisetty, J. B.; Pullagurla, M. R.; Dukat, M.; Setola, V.; Roth, B, L.; Glennon, R. A. 1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands. Bioorg. Med. Chem. Lett. 2005, 15, 1707-1711.
  • 86. Kolanos, R.; Siripurapu, U.; Pullagurla, M.; Riaz, M.; Setola, V.; Roth, B. L.; Dukat, M.; Glennon, R. A. Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. Bioorg. Med. Chem. Lett. 2005, 15, 1987-1991.
  • 87. Setola, V.; Dukat, M.; Glennon, R. A.; Roth, B. L. Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor. Mol. Pharmacol. 2005, 68, 20-33.
  • 88. Ramunno, A.; Dukat, M.; Lee, M.; Young, R.; El-Zahabi, M.; Damaj, I.; Martin, B.; Glennon, R. A. 6-(2-Phenylethyl)nicotine: A novel nicotinic cholinergic receptor ligand. Bioorg. Med. Chem. Lett. 2005, 15, 3237-3240.
  • 89. Abate, C.; Kolanos, R.; Dukat, M.; Setola, V.; Roth, B. L.; Glennon, R. A. Interaction of chiral MS-245 analogs at h5-HT6 receptors. Bioorg. Med. Chem. Lett. 2005, 15, 3510-3513.
  • 90. Dukat, M.; Ramunno, A.; Banzi, R.; Damaj, M. I.; Martin, B.; Glennon, R. A. 3-(2-Aminoethyl)pyridine analogs as alpha4beta2 nicotinic cholinergic receptor ligands. Bioorg. Med. Chem. Lett. 2005, 15, 4308-4312.
  • 91. Bondareva, T.; Wesolowska, A.; Dukat, M.; Lee, M.; Young, R.; Glennon, R. A. S(+) and R(-)N-methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) as discriminative stimuli: effect of cocaine. Pharmacol. Biochem. Behav. 2005, 82, 531-538.
  • 92. Pullagurla, M.; Dukat, M.; Roth, B. L.; Setola, V.; Glennon, R. A. 5-Azatryptamine analogs as h5-HT6 receptor ligands. Med. Chem. Res. 2005, 14, 1-18.
  • 93. Pullagurla, M.; Siripurapu, U.; Kolanos, R.; Bondarev, M.; Dukat, M.; Setola, V.; Roth, B. L.; Glennon, R. A. Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptor. Bioorg. Med. Chem. Lett. 2005, 15, 5298-5302.
  • 94. Dukat, M.; Wesolowska, A. Antinociception: Mechanistic studies on the action of MD-354 and clonidine. Part 1. The 5-HT3 component. Eur. J. Pharmacol. 2005, 528, 59-64.
  • 95. Young, R.; Rothamn, R.; Rangisetty, J. B.; Dukat, M.; Glennon, R. A. TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline) inhibits the consumption of between-meals “snaks” in mice. Pharmacol. Biochem. Behav. 2006, 84, 74-83.
  • 96. Young, R.; Batkai, S.; Dukat, M.; Glennon, R. A. TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline) exhibits anxiolytic-like activity in a marble-burying assay in mice. Pharmacol. Biochem. Behav. 2006, 84, 62-73.
  • 97. Siripurapu, U.; Kolanos, R.; Dukat, M.; Roth, B.L.; Glennon, R.A, Binding of methoxy-substituted N1-benzenesulfonylindole analogs at human 5-HT6 serotonin receptors. Bioorg. Med. Chem. Lett. 2006, 16, 3793-3796.
  • 98. Ragab, H.M.; Kim, J.S.; Dukat, M.; Navarro, H.; Glennon, R.A. Aryloxyethylamines: Binding at alpha7 nicotinic acetylcholine receptors. Bioorg. Med. Chem. Lett. 2006,16, 4283-4286.
  • 99. Sikazwe, D.M.N.; Bondarev, M.L.; Dukat, M.; Rangisetty, J.B.; Roth, B.L.; Glennon, R.A. Binding of Sulfonyl-Containing Arylalkylamines at Human 5-HT6 Serotonin receptors. J. Med. Chem. 2006, 49, 5217-5225.
  • 100. Kolanos, R.; Dukat, M.; Roth, B.L.; Glennon, R.A. Interaction of N1-unsubstituted and N1- benzenesulfonyltryptamines at h5-HT6 receptors. Bioorg. Med. Chem. Lett. 2006, 16, 5832-5835.
  • 101. Dukat, M.; Glennon, R.A.; Young S. MD-354: what is it good for? CNS Drug Rev. 2007, 13, 1-20.
  • 102. Dukat, M.; Wesolowska, A, Young, R.; Glennon, R.A. The 5-HT3 receptor partial agonist MD-354 (meta-chlorophenylguanidine) enhances the discriminative stimulus actions of (+)amphetamine in rats. Pharmacol. Biochem. Behav. 2007, 87, 203-207.
  • 103. Dukat, M.; Mosier, P.D.; Kolanos, R.; Roth, B.L.; Glennon, R.A. Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies. J. Med. Chem. 2008, 51, 603-611.
  • 104. Glennon, R. A.; Siripurapu, U.; Roth, B.; Kolanos, R.; Bondarev, M. L.; Sikazwe, D.; Lee, M.; Dukat, M. The medicinal chemistry of 5-HT6 receptor ligands with a focus on arylsulfonyltryptamine analogs. Current Topics in Med. Chem. 2009.