Publications
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Books/Book Chapters
- Book chapters from the past five years:
- 46. Glennon, R. A. Medicinal chemistry of alpha4beta2 nicotinic cholinergic receptor ligands, In: Progress in Medicinal Chemistry, Volume 42, Elsevier Science B. V., Amsterdam, 2004, 55-123.
- 47. Glennon, R. A. Neurobiology of hallucinogens. In: Textbook of Substance Abuse Treatment, M. Galanter and H. D. Kleber, eds., American Psychiatric Publishing, Washington DC, 2004, pp 41-46.
- 48. Ablordeppey, S. Y.; Glennon, R. A. Pharmacophore models for sigma1 receptor binding, In: Sigma Receptors, Chemistry, Cell Biology and Clinical Implications, Matsumoto, Rae, R.; Bowen, Wayne, D.; Su, Tsung-Ping (Eds.). 2007.
- 49. Glennon, R. A. Strategies for the development of selective serotonergic agents. In: The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics, B. L. Roth, ed., Humana Press, NJ., 2008.
- 50. Glennon, R. A. Hallucinogens, stimulants, and related drugs of abuse, In: Foye’s Textbook of Medicinal Chemistry, D. A. Williams and T. Lemke, eds., Williams and Wilkins, Baltimore, 2008. pp 631-651.
- 51. Glennon, R. A.; Dukat, M. Serotonin receptors and drugs affecting serotonergic neurotransmission, In: Foye’s Textbook of Medicinal Chemistry, D. A. Williams and T. Lemke, eds., Williams and Wilkins, Baltimore, 2008. pp 417-443.
- 52. Glennon, R. A. Neurobiology of hallucinogens. In: Textbook of Sub stance Abuse Treatment, M. Galanter and H. D. Kleber, eds., American Psychiatric Publishing, Washington DC, 2008, pp 181-189.
- 53. Glennon, R. A. The pharmacology of classical hallucinogens and designer drugs. In: Principles of Addiction Medicine, A. W. Graham, T. K. Schultz, M. Mayo-Smith, R. K. Ries and B. B. Wilford, eds., American Society of Addiction Medicine, Chevy Chase, MD., in press.
- 54. Glennon, R. A.[ Iverson, L. Antidepressants, In: Burger's Medicinal Chemistry and Drug Discovery, Nervous System Agents, D. J. Abraham, ed., Wiley: New York. 2003. In press.
Recent Publications
- Representative publications from the past five years:
- 308. Glennon, R. A.; Dukat, M.; alpha4beta2 nACh Receptor Pharmacophore Models. Bioorg. Med. Chem. Lett. 2004,14, 1841-1844.
- 309. Glennon, R. A.; Dukat, M. Musings on alpha4beta2 nicotinic acetylcholine (nACh) receptor pharmacophore models. Curr. Topics Med. Chem. 2004, 4, 631-644.
- 310. Glennon, R. A.; Grella, B.; Tyacke, R J.; Lau, A.; Westaway, J.; Hudson, A. L. Binding of ?-carbolines at imidazoline I2 receptors: Structure-affinity investigation. Bioorg. Med. Chem. Lett. 2004, 14, 999-1002.
- 311. Chang-Fong, J.; Tyacke, R. J.; Lau, A.; Westaway, J.; Hudson, A. L.; Glennon, R. A. Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I2 receptor ligands. Bioorg. Med. Chem. Lett. 2004, 14, 1003-1005.
- 312. Tyacke, R. J.; Lau, A.; Grella, B.; Glennon, R. A.; Nutt, D. J.; Hudson, A. L. Investigation of the affinities of two new ?-carbolines for rat brain imidazoline2 receptors. Ann. N. Y. Acad. Sci. 2004,1009, 361-363.
- 313. Chang-Fong, J.; Rangisetty, J. B.; Dukat, M.; Setola, V.; Raffay, T.; Roth, B.; Glennon, R. A. 1,2,3,4-Tetrahydrocarbazoles as 5-HT6 serotonin receptor ligands. Bioorg. Med. Chem. Lett. 2004, 14, 1961-1964.
- 314. Glennon, R. A.; Ismaiel, A. M.; Ablordeppey, S.; El-Ashmawy, M.; Fisher, J. B. Thioxanthene-derived analogs as sigma-1 receptor ligands. Bioorg. Med. Chem. Lett. 2004,14, 2217-2220.
- 315. Dukat, M.; Smith, C.; Herrick-Davis, K.; Teitler, M.; Glennon, R. A. Binding of tryptamine analogs at h5-HT1E receptors: A structure-affinity investigation. Bioorg. Med. Chem. 2004, 12, 2545-2552.
- 316. Khorana, N.; Pullagurla, M. R.; Young, R.; Glennon, R. A. Comparison of the discriminative stimulus effects of 3,4-methylenedioxymeth amphet- amine (MDMA) and cocaine: Asymmetric generalization. Drug Alcohol Depend. 2004, 74, 281-287.
- 317. Dukat, M.; Taroua, M.; Dahdouh, A.; Siripurapu, U.; Damaj, M.; Martin, B. R.; Glennon, R. A. (?)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents. Bioorg. Med. Chem. Lett. 2004, 14, 3651-3654.
- 318. Pullagurla, M. R.; Bondareva, T.; Young, R.; Glennon, R. A. Modulation of the stimulus effects of (+)amphetamine by the 5-HT6 antagonist MS-245. Pharmacol. Biochem. Behav. 2004, 78, 263-268.
- 319. Pullagurla, M. R.; Westkaemper, R. B.; Glennon, R. A. Possible differences in modes of binding of agonist and antagonist binding at human 5-HT6 receptors. Bioorg. Med. Chem. Lett. 2004, 14, 4569-4573.
- 320. Prisinzano, T.; Dukat, M.; Law, H.; Slassi, A.; MacLean, N. A.; DeLannoy, I.; Glennon, R. A. 2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands. Bioorg. Med. Chem. Lett. 2004, 14, 4697-4699.
- 321. Khorana, N.; Pulagurla, M. R.; Dukat, M.; Young, R.; Glennon, R. A. Stimulus effects of three sulfur-containing psychoactive agents. Pharmacol. Biochem. Behav. 2004, 78, 821-826.
- 322. Glennon, R. A. Nicotine and pain. Med. Chem. Res. 2004, 13, 74-77.
- 323. Glennon, R. A.; Bondarev, M. L.; Khorana, N.; Young, R.; May, J. A.; Hellberg, R. R.; McLaughlin, M. A.; Sharif, N. A. ?-Oxygenated analogs of the 5-HT2A serotonin agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane (DOB). J. Med. Chem. 2004, 47, 6034-6041.
- 324. Lee, M.; Rangisetty, J. B.; Pullagurla, M. R.; Dukat, M.; Setola, V.; Roth, B. L.; Glennon, R. A. 1-(1-Naphthyl)piperazines as a novel template for 5-HT6 serotonin receptor ligands. Bioorg. Med. Chem. Lett. 2005, 15, 1707-1711.
- 325. Kolanos, R.; Siripurapu, U.; Pullagurla, M. R.; Riaz, M.; Setola, V.; Roth, B. L.; Glennon, R. A. Binding of iso-tryptamines and indenes at h5-HT6 serotonin receptors. Bioorg. Med. Chem. Lett. 2005, 15, 1987-1991.
- 326. Setola, V.; Dukat, M.; Glennon, R. A.; Roth, B. L. Molecular determinants for the interaction of the vavulopathic anorexigen norfenfluramine with the 5-HT2B receptor. Mol. Pharmacol. 2005, 68, 20-33.
- 327. Ramunno, A.; Dukat, M.; Lee, M.; Young, R.; El-Zahabi, M.; Damaj, M. I.; Martin, B.; Glennon, R. A. 6-(2-Phenylethyl)nicotine: A novel nicotinic cholinergic receptor ligand. Bioorg. Med. Chem. Lett. 2005, 15, 3237-3240.
- 328. Abate, C.; Kolanos, R.; Dukat, M.; Setola, V.; Roth, B. L.; Glennon, R. A. Interaction of chiral MS-245 analogs at 5-HT6 receptors. Bioorg. Med. Chem. Lett. 2005, 15, 3510-3513.
- 329. Dukat, M.; Ramunno, A.: Banzi, R.; Damaj, I. M.; Martin, B.; Glennon, R. A. 3-(2-Aminoethyl)pyridine analogs as ?4?2 nicotinic cholinergic receptor ligands. Bioorg. Med. Chem. Lett. 2005, 15, 4308-4312.
- 330. Glennon, R. A. Pharmacophore identification for sigma1 receptor binding. Mini-Rev. Med. Chem. 2005, 5, 927-940.
- 331. Pullagurla, M.; Dukat, M.; Roth, B. L.; Setola, V.; Glennon, R. A. 5-Azatryptamine analogs as h5-HT6 receptor ligands. Med. Chem. Res. 2005, 14, 1-18.
- 332. Pullagurla, M.; Siripurapu, U.; Kolanos, R.; Bondarev, M. L.; Dukat, M.; Setola, V.; Roth, B. L.; Glennon, R. A. Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors. Bioorg. Med. Chem. Lett. 2005, 15, 5298-5302.
- 333. Young, R.; Khorana, N.; Bondareva, T.; Glennon, R. A. Pizotyline effectively attenuates the stimulus effects of N- methyl-3,4-methylenedioxyamphetamine (MDMA). Pharmacol. Biochem. Behav. 2005
- 334. Glennon, R. A. Binding characteristics of sigma2 receptor ligands. Brazil. J. Pharm. Sci. 2005, 41,1-12.
- 335. Bondareva, T.; Wesolowska, A.; Dukat, M.; Lee, M.; Young, R.; Glennon, R. A. S(+)- and R(-)N-methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) as discriminative stimuli: Effect of cocaine. Pharmacol Biochem Behav. 2005, 82, 531-538.
- 336. Young, R.; Bondareva, T.; Wesolowska, A.; Glennon, R. A. Modulation of a (+)amphetamine discriminative stimulus in rats by 8-hydroxy-2-(N,N-di-n-propylamino)tetralin (8-OH DPAT). Pharmacol. Biochem. Behav. 2006, 83, 612-617.
- 337. Siripurapu, U.; Kolanos, R.; Dukat, M.; Roth, B. L.; Glennon, R. A. Binding of methoxy-substituted N1-benzenesulfonylindole analogs at human 5-HT6 serotonin receptors. Bioorg. Med. Chem. Lett. 2006, 16, 3793-6.
- 338. Young, R.; Rothman, R. B.; Rangisetty, J. B.; Partilla, J. S.; Dukat, M.; Glennon, R. A. TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline) inhibits the consumption of "snacks" in mice. Pharmacol. Biochem. Behav. 2006, 84, 74-83.
- 339. Young, R.; Batkai,,S.; Dukat, M.; Glennon, R. A. TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline) exhibits anxiolytic-like activity in a marble-burying assay in mice. Pharmacol. Biochem. Behav. 2006, 84, 62-73.
- 340. Ragab, H. M.; Kim, J. S.; Dukat, M.; Navarro, H.; Glennon, R. A. Aryloxyethylamines: binding at alpha7 nicotinic acetylcholine receptors. Bioorg. Med. Chem. Lett. 2006, 16, 4283-4276.
- 341. Sikazwe, D.; Bondarev, M. L.; Dukat, M.; Rangisetty, J. B.; Roth, B. L.; Glennon, R. A. Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. J. Med. Chem. 2006, 49, 5217-5225.
- 342. Kolanos, R.; Dukat, M.; Roth, B. L.; Glennon, R. A. Interaction of N1-unsubstituted and N1-benzenesulfonyltryptamines at h5-HT6 receptors. Bioorg. Med. Chem. Lett. 2006 16, 5832-5835.
- 343. Young, R.; Bondareva, T.; Wesolowska, A.; Young, S.; Glennon, R. A. Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (-) nicotine. Pharmacol. Biochem. Behav. 2006 83, 612-617.
- 344. Glennon, R. A.; Bondareva, T,; Young, R. ?-Ethyltryptamine (alpha-ET) as a discriminative stimulus in rats. Pharmacol. Biochem. Behav. 2006, 85, 448-453.
- 345. Glennon, R. A. 3-(4-Tetrahydropyridin-1-yl)butyl)oxindoles as 5-HT7 receptor ligands. Expert Opin. Ther. Patents 2006, 16, 1171-1174.
- 346. Nyandege, A.; Kolanos, R.; Roth, B. L.; Glennon, R. A. Further studies on the binding of N1-substituted tryptamines at h5-HT6 serotonin receptors. Bioorg. Med. Chem. Lett. 2007, 17. 1691-1694.
- 347. Glennon, R. A.; Young, R.; Dukat, M.; Chang-Fong, J.; El-Zahabi, M. N-Methyl-1-(4-methoxyphenyl)-2-aminopropane (PMMA) and N-Methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) produce non-identical discriminative stimuli in rats. Pharmacol. Biochem. Behav. 2007 86, 477-484.
- 348. Dukat, M.; Glennon, R. A.; Young, S. MD-354: what is it good for? CNS Drug Rev. 2007, 13, 1-20.
- 349. Dukat, M.; Wesolowska, A.; Young, R.; Glennon, R. A. The 5-HT3 receptor partial agonist MD-354 (meta-chlorophenylguanidine) enhances the discriminative stimulus actions of (+)amphetamine in rats. Pharmacol. Biochem. Behav. 2007, 87, 203-207.
- 350. Kim, J. S.; Padnya, A.; Weltzin, M.; Edmonds, B. W.; Schulte, M. K.; Glennon, R. A. Synthesis of desformylflustrabromine and its evaluation as an alpha4beta2 and alpha7 nACh receptor modulator. Bioorg. Med. Chem. Lett. 2007, 17, 4855-4860.
- 351. De Oliviera, E.; Brandt, C. A.; Da Silviera, M. A.; Glennon, R. A. Synthesis of pyrrolidine-substituted benzamides via iodocyclization of beta-enaminoesters. Tetrahedron Lett. 2008, 48, 6393-6396.
- 352. Young, R. A.; Glennon, R. A. MDMA (N-methyl-3,4-methylene- dioxyamphetamine) and its stereoisomers: Similarities and differences in behavioral effects in an automated activity apparatus in mice. Pharmacol. Biochem. Behav. 2008, 88, 318-331.
- 353. Dukat, M.; Mosier, P. D.; Kolanos, R.; Roth, B. L.; Glennon, R. A. Binding of Serotonin and N1-Benzenesulfonyltryptamine-Related Analogs at Human 5-HT6 Serotonin Receptors: Receptor Modeling Studies. J. Med. Chem. 2008, 51, 603-611.
- 354. Runyon, S. P.; Mosier, P. D.; Roth, B. L.; Glennon, R. A.; Westkaemper, R. B. Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation. J. Med. Chem. 2008, 51, 6808-6828.
- 355. May, J. A.; Sharif, N. A.; Chen, H. H.; Liao, J. C.; Kelly, C. R.; Glennon, R. A.; Young, R.; Li, J. X.; Rice, K. C.; France, C. P. Pharmacological properties and discriminative stimulus effects of a novel and selective 5-HT2 receptor agonist AL-38022A [(S)-2-(8,9-dihydro-7H-pyrano[2,3-g]indazol-1-yl)-1-methylethylamine]. Pharmacol. Biochem. Behav. 2009, 91, 307-314.
- 356. Khorana, N.; Young, R.; Glennon, R. A. Effect of 8-hydroxy-2-(N,N-di-n-propylamino)tetralin and MDMA on the discriminative stimulus effects of the classical hallucinogen DOM in rats. Pharmacol. Biochem. Behav. 2009, 91, 385-392.
- 357. Young, R.; Glennon, R. A. S(-)Propranolol as a discriminative stimulus and its comparison to the stimulus effects of cocaine in rats. Psychopharmacology (Berl) 2009, 203, 369-382.
- 358. Abate, C.; Mosier, P. D.; Berardi, F.; Glennon, R. A. A structure-affinity and comparative molecular field analysis of sigma-2 receptor ligands. Central Nerv. System Agents in Med. Chem. In press.
- 359. Glennon, R. A.: Siripurapu, U.; Dukat, M.; Roth, B. L.; Kolanos, R.; Bond- arev, M. L.; Sikazwe, D.; Lee, M. The medicinal chemistry of 5-HT6 receptor ligands with a focus on arylsulfonyltryptamines. Curr. Topics Med. Chem. In press.