Faik N Musayev, Ph.D
Research Assistant Professor
Department of Medicinal Chemistry

Area of Focus

  • Rational development of drugs for diseases, with practical application of X-ray Crystallography

Education

  • B.S., Chemistry (Azerbaijan Pedagogical University, Former USSR, 1973)
  • Ph.D., Inorganic Chemistry/X-ray Crystallography (Institute of Inorganic & Physical Chemistry, Academy of Science, Former USSR, 1991)

Post-Graduate Training

  • Research Scientist - Small Molecular X-ray Crystallography (Institute of Inorganic & Physical Chemistry, Academy of Science, Former USSR, 1991)
  • Postdoc - Biochemistry and Protein X-ray Crystallography (Institute of Molecular Biology, Academia Sinica, Taiwan, 1993)
  • Postdoc - Macromolecular X-ray Crystallography and Medicinal Chemistry (Virginia Commonwealth University, 1998)

Professional Experience

  • (2004 - Present) Research Assistant Professor, Virginia Commonwealth University
  • (2010 - Present) Manager Structural Biology Core Laboratory, Virginia Commonwealth University

Research Interests

  • My primary research interest is aimed at understanding structure-function relationship of macromolecules with a practical emphasis on pharmacology
  • Structure-Based Drug Design
  • Protein-Ligand, Protein-DNA interactions
  • Small and Macromolecular X-ray Crystallography
  • Stereochemistry of chiral compounds

Publications

PubMed Search
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Recent Publications

  • 1.B.R. Belvin, F.N. Musayev, J. Burnger, J.N. Scarsdale, C.R. Escalante, J.P. Lewis. “Nitrosative stress sensing in Porphromonas gingivalis: structure of and heme binding by the transcriptional regulator HcpR.” Acta Crystallogr D Structural Biol. 2019, 75: 437-450.
  • 2.P.P. Pagare, M.S. Ghatge, F.N. Musayev, T.M. Deshpande, Q. Chen, C. Braxton, S. Kim, J. Venitz, Y. Zhang, O. Abdulmalik, M.K. Safo. “Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease.” Bioorg Med Chem. 2018, 26(9): 2530-2538
  • 3.M.J. Chiang, F.N. Musayev, M. Kosikova, Z. Lin, Y. Gao, P.D. Mosier, B. Althufairi, Z. Ye, Q. Zhou, U.R. Desai, H. Xie, M.K. Safo. “Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.” Emerg Microbes Infect. 2017 Dec 6; 6(12):e108. doi: 10.1038/emi.2017.96.
  • 4.F.N. Musayev, F. Zarate-Perez F, C. Bishop, J.W. Burgner, C.R. Escalante. “Structural Insights into the Assembly of the Adeno-associated Virus Type 2 Rep68 Protein on the Integration Site AAVS1.” J Biol Chem. 2015, 290(46): 27487-99.
  • 5.F.N. Musayev, F. Zarate-Perez, M. Bardelli, C. Bishop, E.F. Saniev, R.M. Linden, E. Henckaerts, C.R. Escalante. “Structural Studies of AAV2 Rep68 Reveal a Partially Structured Linker and Compact Domain Conformation.” Biochemistry, 2015, 54(38): 5907-19.
  • 6.S. Boundy, M.K. Safo, L. Wang, F.N. Musayev, H.C. O'Farrell, J.P. Rife, G.L. Archer. “Characterization of the Staphylococcus aureus rRNA methyltransferase encoded by orfX, the gene containing the staphylococcal chromosome Cassette mec (SCCmec) insertion site.” J Biol Chem. 2013, 288(1): 132-40.
  • 7.X. Xu, F. Marni, S. Wu, Z. Su, F. Musayev, S. Shrestha, C. Xie, W. Gao, Q. Liu, L. Zhou. “Local and global interpretations of a disease-causing mutation near the ligand entry path in hyperpolarization-activated cAMP-gated channel.” Structure. 2012, 20(12): 2116-23.
  • 8.F.N. Musayev, M.L. Di Salvo, M.A. Saavedra, R. Contestabile, M.S. Ghatge, A. Haynes, V. Schirch, M.K. Safo. Molecular basis of reduced pyridoxine 5'-phosphate oxidase catalytic activity in neonatal epileptic encephalopathy disorder. J Biol Chem. 2009, 284(45): 30949-56.
  • 9.F. Musayev, S. Sachdeva, J.N. Scarsdale, K.A. Reynolds, H.T. Wright. “Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A.” J Mol Biol. 2005, 346(5): 1313-21.
  • Link to ResearchGate Profile https://www.researchgate.net/profile/Faik_Musayev