Faik N Musayev, Ph.D
Research Associate Professor
Department of Medicinal Chemistry
Faculty/Staff picture
  •   BioTech One, Suite 212
  • School of Pharmacy - Dept of Medicinal Chemistry
    BioTech One, Suite 205
    800 E. Leigh St.
    Box 980540
    Richmond, VA 23298-0540
  •  (804) 828-4875
    (804) 8273664

Area of Focus

  • Rational development of drugs for diseases, with practical application of X-ray Crystallography


  • B.S., Chemistry (Azerbaijan Pedagogical University, Former USSR, 1973)
  • Ph.D., Inorganic Chemistry/X-ray Crystallography (Institute of Inorganic & Physical Chemistry, Academy of Science, Former USSR, 1991)

Post-Graduate Training

  • Research Scientist - Small Molecular X-ray Crystallography (Institute of Inorganic & Physical Chemistry, Academy of Science, Former USSR, 1991)
  • Postdoc - Biochemistry and Protein X-ray Crystallography (Institute of Molecular Biology, Academia Sinica, Taiwan, 1993)
  • Postdoc - Macromolecular X-ray Crystallography and Medicinal Chemistry (Virginia Commonwealth University, 1998)

Professional Experience

  • (2004 - Present) Research Assistant Professor, Virginia Commonwealth University
  • (2010 - Present) Manager Structural Biology Core Laboratory, Virginia Commonwealth University

Research Interests

  • My primary research interest is aimed at understanding structure-function relationship of macromolecules with a practical emphasis on pharmacology
  • Structure-Based Drug Design
  • Protein-Ligand, Protein-DNA interactions
  • Small and Macromolecular X-ray Crystallography
  • Stereochemistry of chiral compounds


PubMed Search
The publications search is performed on the National Library of Medicine's PubMed database. The search may be slow during high traffic hours, may return articles authored by another researcher with a similar name and may not always find all of a researcher's articles.

Recent Publications

  • 1.B.R. Belvin, F.N. Musayev, J. Burnger, J.N. Scarsdale, C.R. Escalante, J.P. Lewis. “Nitrosative stress sensing in Porphromonas gingivalis: structure of and heme binding by the transcriptional regulator HcpR.” Acta Crystallogr D Structural Biol. 2019, 75: 437-450.
  • 2.P.P. Pagare, M.S. Ghatge, F.N. Musayev, T.M. Deshpande, Q. Chen, C. Braxton, S. Kim, J. Venitz, Y. Zhang, O. Abdulmalik, M.K. Safo. “Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease.” Bioorg Med Chem. 2018, 26(9): 2530-2538
  • 3.M.J. Chiang, F.N. Musayev, M. Kosikova, Z. Lin, Y. Gao, P.D. Mosier, B. Althufairi, Z. Ye, Q. Zhou, U.R. Desai, H. Xie, M.K. Safo. “Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.” Emerg Microbes Infect. 2017 Dec 6; 6(12):e108. doi: 10.1038/emi.2017.96.
  • 4.F.N. Musayev, F. Zarate-Perez F, C. Bishop, J.W. Burgner, C.R. Escalante. “Structural Insights into the Assembly of the Adeno-associated Virus Type 2 Rep68 Protein on the Integration Site AAVS1.” J Biol Chem. 2015, 290(46): 27487-99.
  • 5.F.N. Musayev, F. Zarate-Perez, M. Bardelli, C. Bishop, E.F. Saniev, R.M. Linden, E. Henckaerts, C.R. Escalante. “Structural Studies of AAV2 Rep68 Reveal a Partially Structured Linker and Compact Domain Conformation.” Biochemistry, 2015, 54(38): 5907-19.
  • 6.S. Boundy, M.K. Safo, L. Wang, F.N. Musayev, H.C. O'Farrell, J.P. Rife, G.L. Archer. “Characterization of the Staphylococcus aureus rRNA methyltransferase encoded by orfX, the gene containing the staphylococcal chromosome Cassette mec (SCCmec) insertion site.” J Biol Chem. 2013, 288(1): 132-40.
  • 7.X. Xu, F. Marni, S. Wu, Z. Su, F. Musayev, S. Shrestha, C. Xie, W. Gao, Q. Liu, L. Zhou. “Local and global interpretations of a disease-causing mutation near the ligand entry path in hyperpolarization-activated cAMP-gated channel.” Structure. 2012, 20(12): 2116-23.
  • 8.F.N. Musayev, M.L. Di Salvo, M.A. Saavedra, R. Contestabile, M.S. Ghatge, A. Haynes, V. Schirch, M.K. Safo. Molecular basis of reduced pyridoxine 5'-phosphate oxidase catalytic activity in neonatal epileptic encephalopathy disorder. J Biol Chem. 2009, 284(45): 30949-56.
  • 9.F. Musayev, S. Sachdeva, J.N. Scarsdale, K.A. Reynolds, H.T. Wright. “Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A.” J Mol Biol. 2005, 346(5): 1313-21.
  • Link to ResearchGate Profile https://www.researchgate.net/profile/Faik_Musayev