Douglas H Sweet, PhD
Chairman
E. Claiborne Robins Professor
Department of Pharmaceutics
Faculty/Staff picture
  •   Smith Building, Room 454A
  • School of Pharmacy - Dept of Pharmaceutics
    410 N 12th Street
    P.O. Box 980533
    Richmond, VA 23298-0533
  •  (804) 828-3860
    (804) 828-8359

Education

  • B.S., Biology (University of Michigan, 1984)
  • M.S., Biology (University of Michigan, 1987)
  • Ph.D., Biology (University of Michigan, 1993)

Post-Graduate Training

  • Post Doctoral Fellow - DNA Repair Mechanisms (Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill (1993-, 1995)
  • Intramural Research Training Fellow - Renal Organic Solute Transport (Laboratory of Pharmacology and Chemistry, Renal Pharmacology Section, NIH/NIEHS (1995-, 2000)

Professional Experience

  • (2015 - Present) Professor and Chair, Department of Pharmaceutics, Virginia Commonwealth University
  • (2008 - 2015) Associate Professor, Department of Pharmaceutics, Virginia Commonwealth University
  • (2007 - 2008) Associate Professor, Department of Pharmaceutical Sciences, Medical University of South Carolina
  • (2002 - 2007) Assistant Professor, Department of Pharmaceutical Sciences, Medical University of South Carolina
  • (2000 - 2002) Assistant Project Scientist, Department of Medicine/Nephrology, University of California, San Diego

Professional and Scholarly Interests

  • Comparative Physiology and Toxicology of Epithelial Transport

Research Interests

  • Organisms encounter a diverse array of potentially hazardous substances on a daily basis, including medications, plant and animal toxins, and products of cellular metabolism. An individual's ability to survive these exposures greatly depends upon the efficiency of the excretory and detoxifying organs of the body (e.g., liver, kidney, choroid plexus). Our research focus is on the proteins responsible for the transport of organic solutes in renal proximal tubule, choroid plexus, and brain capillary endothelium. Understanding the mechanisms these transporters utilize to protect the body and brain from fluctuations in the composition of the blood and cerebrospinal fluid will provide unique insight into toxicity, drug-drug interaction, and human disease states. We use Xenopus oocyte, cell culture, intact tissue, and knockout mouse model systems to: (1) determine the energetics and specificity of the transporters, (2) define the roles of transporters in drug interactions and disease, and (3) identify the mechanisms involved in the modulation of transporter function and expression.

Publications

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