Yana Cen
Assistant Professor
Department of Medicinal Chemistry
Faculty/Staff picture
  • School of Pharmacy - Dept of Medicinal Chemistry
    BioTech One, Suite 205
    800 E. Leigh St.
    P.O. Box 980540
    Richmond, VA 23298-0540
  •  (804) 828-7405

Area of Focus

  • Epigenetics, Sirtuins, Chemical Biology

Education

  • B.S., Chemistry (Beijing Normal University, 1998)
  • M.S., Organic Chemistry (Beijing Normal University, 2001)
  • Ph.D., Organic Chemistry (Michigan State University, 2006)

Post-Graduate Training

  • Postdoctoral - Pharmacology (Cornell Medical School, 2011)

Professional Experience

  • (2011 - 2012) Instructor, Cornell Medical School
  • (2012 - 2014) Research Scientist II, University of Texas Medical Branch
  • (2014 - 2019) Assistant Professor, Albany College of Pharmacy and Health Sciences
  • (2019 - Present) Assistant Professor, Virginia Commonwealth University

Research Interests

  • Design and Synthesis of Chemical Probes for Epigenetic Modification Enzymes
  • Development of Chemical Tools to Study DNA Modifications
  • Targeting NAD metabolism for Drug Discovery

Publications

Books/Book Chapters

  • Cen, Y., “Natural Products as CNS Stimulants” In Pharmacognosy; Zhang, Y. Eds.; Cognella Academic Publishing: San Diego, California, USA.

Patents

  • Sauve, A. A.; Cen, Y., “2-Fluorinated Riboses and Arabinoses and Methods of Use and Synthesis”, U.S. Patent No. 9,790,252
  • Sauve, A. A.; Cen, Y., “Reagents and Methods for Sirtuin Capture”, U.S. Patent No. 9,290,791

Recent Publications

  • Curry, A.; Cohen, I.; Zheng, S.; Wohlfahrt, J.; White, D.; Donu, D.; Cen, Y.*, “Profiling Sirtuin Activity Using Copper-free Click Chemistry”, Bioorganic Chemistry, in press.
  • Curry, A.; White, D.; Donu, D.; Cen, Y.*, “Human Sirtuin Regulators: the Success Stories”, Frontier in Physiology, accepted.
  • Curry, A.; White, D.; Cen, Y.*, “Small Molecule Regulators Targeting NAD+ Biosynthetic Enzymes”, Current Medicinal Chemistry, 2021, online ahead of print. doi:10.2174/0929867328666210531144629.
  • Rymarchyk, S.; Kang, W.; Cen, Y.*, “Substrate-dependent Sensitivity of SIRT1 to Nicotinamide Inhibition”, Biomolecules, 2021, 11, 312.
  • Curry, A. M.; Barton, E.; Kang, W.; Mongeluzi, D. V.; Cen, Y.*, "Development of Second Generation Activity-based Chemical Probes for Sirtuins", Molecules, https://www.mdpi.com/1420-3049/26/1/11.
  • Hoyle, R.; Wang, H.; Cen, Y.; Zhang, Y.; Li, J., “IOX1 Suppresses Wnt Target Gene Transcription and Colorectal Cancer Tumorigenesis Through Inhibition of KDM3”, Molecular Cancer Therapeutics, doi: 10.1158/1535-7163.MCT-20-0328.
  • Carraway, H.; Malkaram, S.; Cen, Y.; Fan, J.; Ali, H.; Abd Elmageed, Z.; Buttolph, T.; Shatnawi, A.; Denvir, J.; Primerano, D.; Fandy, T., “Activation of SIRT6 by DNA hypomethylating agents and clinical consequences on combination therapy”, Scientific Reports, 2020, 10, 10325.
  • Zheng, S.; Wohlfahrt, J.; Cohen, I.; Cen, Y.*, “Methods for Studying Human Sirtuins with Activity-based Chemical Probes”, Methods in Enzymology, 2020, 633, 251-269.
  • Tran, A.; Yokose, R.; Cen, Y.*, “Chemo-enzymatic Synthesis of Isotopically Labeled Nicotinamide Riboside”, Organic and Biomolecular Chemistry, 2018, 16, 3662-3671.
  • Graham, E.; Rymarchyk, S.; Wood, M.; Cen, Y.*, “Development of Activity-Based Chemical Probes for Human Sirtuins”, ACS Chemical Biology, 2018, 13, 782-792.
  • Wood, M.; Rymarchyk, S.; Zheng, S.; Cen, Y.*, “Trichostatin A inhibits deacetylation of histone H3 and p53 by SIRT6”, Archives of Biochemistry and Biophysics, 2018, 638, 8-17.